Caveolin-1 (Phospho-Tyr14) Colorimetric Cell-Based ELISA Kit

Store at 4°C for up to 6 months.

CAV1

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564).

The Caveolin-1 (Phospho-Tyr14) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Caveolin-1 (Phospho-Tyr14) protein expression profile in cells. The kit can be used for measuring the relative amounts of Caveolin-1 (Phospho-Tyr14) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Caveolin-1 (Phospho-Tyr14).

Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain.