BL-CAM (Phospho-Tyr807) Colorimetric Cell-Based ELISA Kit

Store at 4°C for up to 6 months.

CD22

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

The BL-CAM (Phospho-Tyr807) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor BL-CAM (Phospho-Tyr807) protein expression profile in cells. The kit can be used for measuring the relative amounts of BL-CAM (Phospho-Tyr807) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on BL-CAM (Phospho-Tyr807).

B-lymphocytes.