Vergleich

Rat SCF/KITLG/Kit ligand ELISA Kit PicoKine®

Hersteller Boster
Kategorie
Typ Elisa-Kit
Specific against Rat
Applikationen ELISA
Menge 96 wells/kit, with removable strips.
ArtNr BOS-EK0508
Targets IL2
eClass 6.1 32160605
eClass 9.0 32160605
Lieferbar
Manufacturers Product Category
PicoKine® ELISA Kits
Manufacturers Research Category
Cytokines, Developmental Biology, Embryogenesis, Embryonic Stem Cells, Immunology, Innate Immunity, Stem Cells, Surface Molecules
Short Description
Rat SCF ELISA Kit PicoKine® (96 Tests). Quantitate Rat Kitlg in cell culture supernatants, serum and plasma (EDTA). Sensitivity: 10pg/ml.
Description
Rat SCF ELISA Kit PicoKine® (96 Tests). Quantitate Rat Kitlg in cell culture supernatants, serum and plasma (EDTA). Sensitivity: 10pg/ml.
Background
Stem Cell Factor (also known as SCF, kit-ligand, KL, or steel factor) is a cytokine that binds to the c-Kit receptor (CD117). It is mapped to 12q21.32. SCF was primarily expressed by perivascular cells throughout the bone marrow, and it plays a role in the regulation of HSCs in the stem cell niche in the bone marrow. SCF can exist both as a transmembrane protein and a soluble protein. This gene plays an important role in the hematopoiesis during embryonic development. During development, the presence of the SCF also plays an important role in the localization of melanocytes, cells that produce melanin and control pigmentation. In addition to it, SCF can promote mast cell adhesion, migration, proliferation, and survival. It also promotes the release of histamine and tryptase, which are involved in the allergic response.
Gene Name
KITLG
Immunogen
Expression system for standard: E.coli; Immunogen sequence: Q26-A190
Cross-reactivity
There is no detectable cross-reactivity with other relevant proteins.
Sample Type
cell culture supernatants, serum and plasma (EDTA).
Capture antibody|Detection antibody
monoclonal antibody from mouse|polyclonal antibody from goat
Storage
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Anticoagulant
EDTA
Gene Full Name
Kit ligand
Molecular Weight
30712 MW
Protein Function
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1, 4, 5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Subcellular Localization
Isoform 1: Cell membrane ; Single-pass type I membrane protein.
Protein Name
Kit ligand

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 96 wells/kit, with removable strips.
Lieferbar: In stock
lieferbar

Lieferung vsl. bis 02.05.2024 

Vergleichen

Auf den Wunschzettel

Angebot anfordern

Lieferzeit anfragen

Technische Frage stellen

Bulk-Anfrage stellen

Fragen zum Produkt?