ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha Human Recombinant Protein

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Hersteller Boster
Kategorie
Typ Proteins Recombinant
Specific against other
Format Sterile Filtered colorless solution.
Menge 20ug
ArtNr BOS-PROTP52565
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Gene name
ARHGDIA
Conjugate
No
Contents
The ARHGDIA solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol.
Description
ARHGDIA Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 202 amino acids (24-204 a.a.) and having a molecular mass of 22.9kDa. The ARHGDIA is purified by proprietary chromatographic techniques.
Short description
ARHGDIA Human Recombinant fused with a 222.9kDa. The ARHGDIA is purified by proprietary chromatographic techniques.
Uniprot ID
P52565
Purification
Greater than 95.0% as determined by SDS-PAGE.
Storage
Store in -20° C for long term storage. After reconstitution, store in 4° C for short term usage within a few days. Avoid freeze-thaw cycles.
Synonyms
Rho GDP-dissociation inhibitor 1; Rho GDI 1; Rho-GDI alpha; ARHGDIA; GDIA1;
Protein function
Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.
Subcellular localization
Cytoplasm
Source
E. Coli
Shipping
Shipped with wet ice

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Menge: 20ug
Lieferbar: In stock
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