ATXN3 Ataxin-3 Human Recombinant Protein

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Hersteller Boster
Kategorie
Typ Proteins Recombinant
Specific against other
Format Sterile filtered colorless solution.
Menge 10ug
ArtNr BOS-PROTP54252
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Gene name
ATXN3
Conjugate
No
Contents
The ATXN3 protein solution contains 20mM Tris-HCl buffer (pH 7.5), 2mM DTT, 50mM NaCl and 10% glycerol.
Description
ATXN3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 370 amino acids (1-370 a.a.) and having a molecular mass of 42.4kDa.
ATXN3 is purified by proprietary chromatographic techniques.
Short description
ATXN3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 370 amino acids (1-370 a.a.) and having a molecular mass of 42.4kDa.
ATXN3 is purified by proprietary chromatographic techniques.
Uniprot ID
P54252
Purification
Greater than 90.0% as determined by SDS-PAGE.
Storage
Store in -20° C for long term storage. After reconstitution, store in 4° C for short term usage within a few days. Avoid freeze-thaw cycles.
Synonyms
Ataxin-3; 3.4.19.12; Machado-Joseph disease protein 1; Spinocerebellar ataxia type 3 protein; ATXN3; ATX3, MJD, MJD1, SCA3;
Protein function
Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. In response to misfolded substrate ubiquitination, mediates deubiquitination of monoubiquitinated STUB1/CHIP. Interacts with key regulators of transcription and represses transcription: acts as a histone- binding protein that regulates transcription.
Subcellular localization
Nucleus matrix
Tissue specificity
Ubiquitous.
Source
E. Coli
Shipping
Shipped with wet ice

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Menge: 10ug
Lieferbar: In stock
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