USP14 Ubiquitin Specific Peptidase 14 Human Recombinant Protein

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Hersteller Boster
Kategorie
Typ Proteins Recombinant
Specific against other
Format Sterile Filtered colorless solution.
Menge 20ug
ArtNr BOS-PROTP54578
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Gene name
USP14
Conjugate
No
Contents
USP14 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 20% glycerol and 1mM DTT.
Description
USP14 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 517 amino acids (1-494 a.a) and having a molecular mass of 58.5kDa. USP14 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Short description
USP14 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 517 amino acids (1-494 a.a) and having a molecular mass of 58.5kDa. USP14 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Uniprot ID
P54578
Purification
Greater than 90.0% as determined by SDS-PAGE.
Storage
Store in -20° C for long term storage. After reconstitution, store in 4° C for short term usage within a few days. Avoid freeze-thaw cycles.
Synonyms
Ubiquitin carboxyl-terminal hydrolase 14; 3.4.19.12; Deubiquitinating enzyme 14; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14; USP14; TGT;
Protein function
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
Subcellular localization
Cytoplasm
Source
E. Coli
Shipping
Shipped with wet ice

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Menge: 20ug
Lieferbar: In stock
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