Argatroban (MD805; MCI9038; Argipidine)

Description: Argatroban (MD-805; MCI-9038; Argipidine) is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM. Argatroban is used as an anticoagulant that acts as a direct thrombin inhibitor. Argatroban received FDA approval in 2000 for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT). As a direct thrombin inhibitor, Argatroban reversibly binds to the thrombin active site. Argatroban exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions which include fibrin formation, activation of coagulation factors V, VIII, and XIII; activation of protein C, and platelet aggregation as well.

References: Br J Pharmacol. 1994 Dec; 113(4):1209-14; Jpn J Pharmacol. 1995 Oct; 69(2):143-8.

Related CAS #: 141396-28-3 (hydrate); 74863-84-6 (anhydrous);