Fluorofenidone (AKF-PD; AKFPD)

Description: Fluorofenidone(AKF-PD; AKFPD), a derivative of AMR69, a promising multifunctional antifibrosis pyridinone drug which act as a potent inhibitor of nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. It attenuates the progression of renal interstitial fibrosis partly bysuppressing NADPH oxidase and extracellular matrix (ECM) deposition viathe PI3K/Akt signalling pathway.

References:

1. QinJ, et al. Fluorofenidone inhibits nicotinamide adeninedinucleotidephosphate oxidase via PI3K/Akt pathway in the pathogenesis of renalinterstitial fibrosis. Nephrology (Carlton). 2013 Oct; 18(10):690-9.

2. LouQ, et al. Design, synthesis and antifibrotic activities ofcarbohydrate-modified 1-(substituted aryl)-5-trifluoromethyl-2(1H)pyridones. Molecules. 2012 Jan 17; 17(1):884-96.

3. Spermidine-mediated poly(lactic-co-glycolic acid) nanoparticles containing fluorofenidone for the treatment of idiopathic pulmonary fibrosis. Int J Nanomedicine. 2017 Sep 8; 12:6687-6704.