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TBC1D4 Antibody

ArtNr PRS-4415-0.1mg
Hersteller ProSci
Menge 0.1 mg
Quantity options 0.02 mg 0.1 mg
Kategorie
Typ Antibody Polyclonal
Format Liquid
Applikationen ELISA, IHC-P
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Konjugat/Tag Unconjugated
Citations Kane S, Sano H, Liu SCH, et al. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J. Biol. Chem. 2002; 277:22115-8.
Sano H, Kane S, Sano E, et al. Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J. Biol. Chem. 2003; 278:14599-602.
Dash S, Sano H, Rochford JJ, et al. A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia. Proc. Natl. Acad. Sci. U.S.A. 2009; 106:9350–5.
Brewer PD, Romenskaia I, Kanow MA, et al. Loss of AS160 Akt substrate causes Glut4 protein to accumulate in compartments that are primed for fusion in basal adipocytes. J. Biol. Chem. 2011; 286:26287-97.
NCBI TBC1D4
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias TBC1D4 Antibody: AS160,AS160,KIAA0603,TBC1 domain family member 4,Akt substrate of 160 kDa
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Type
Primary Antibodies
Shipping Temperature
Blue Ice
Storage Conditions
TBC1D4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Molecular Weight
Predicted: 143 kDa
Observed: 140 kDa
Manufacturer - Research Area
Homeostasis
Background
TBC1D4 Antibody: TBC1D4, also known as the Akt substrate AS160, was initially identified as an Akt substrate containing a GTPase-activating domain that regulates GLUT4 trafficking, with activation following insulin stimulation. TBC1D4 truncations in humans is a major cause of dominant inherited insulin resistance. The loss of TBC1D4 results in the accumulation of GLUT4 in compartments that are primed for fusion in basal adipocytes.
By Type
Homeostasis
Badges
Trial Size
Modifications
None
Protein Gi #
114688046
Purification
TBC1D4 Antibody is affinity chromatography purified via peptide column.
Positive Control 1
PRS-10-635-4um
Concentration
1 mg/mL
Buffer
TBC1D4 Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note
TBC1D4 antibody can be used for immunohistochemistry starting at 10 μ g/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (89%)
Immunogen
TBC1D4 antibody was raised against an 19 amino acid peptide near the carboxy terminus of human TBC1D4 .

The immunogen is located within amino acids 1190 - 1240 of TBC1D4.
Clonality
Polyclonal
NCBI Official Name
TBC1 domain family, member 4
NCBI Organism
homo sapiens
Disclaimer
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note
Optimal dilutions for each application to be determined by the researcher.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.1 mg
Lieferbar: In stock
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