Rolitetracycline (Pyrrolidinylmethyltetracycline, SQ 15659)

RT

527, 57

Very dark red to very dark brown solid

Rolitetracycline is a tetracycline antibiotic that may be given intravenously or intramuscularly in serious bacterial infections when oral administration is not practicable.

Synonyms:
(4S, 4aS, 5aS, 6S, 12aS)-4-(dimethylamino)-1, 4, 4a, 5, 5a, 6, 11, 12a-octahydro-3, 6, 10, 12, 12a-pentahydroxy-6-methyl-1, 11-dioxo-N-(1-pyrrolidinylmethyl)-2-naphthacenecarboxamide; 4-(Dimethylamino)-1, 4, 4a, 5, 5a, 6, 11, 12a-octahydro-3, 6, 10, 12, 12a-pentahydroxy-6-methyl-1, 11-dioxo-N-(1-pyrrolidinylmethyl)-2-naphthacenecarboxamide; Abricycline; Bristacin; N-(1-Pyrrolidinylmethyl)tetracycline; N-(Pyrrolidinomethyl)tetracycline; Pyrrolidinylmethyltetracycline; Reverin; Rolitetracycline; SQ 15659; Superciclin; Synotodecin; Syntetrin; Tetraverin; Transcycline; Velacycline

CAS Number:
751-97-3

Molecular Formula:
C₂₇H₃₃N₃O₈

Molecular Weight:
527.57

Appearance:
Very dark red to very dark brown solid

Purity:
Technical Grade

Solubility:
DMSO (Slightly), Methanol (Very Slightly)

Atmosphere:
Inert Gas

Method For Determining Identity:
Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric analysis

TLC Conditions:
C18; Water: Acetonitrile: Acetic Acid=8:2:02; Visualized with UV and AMCS; Single Spot, f=0.30

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under inert atmosphere.