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Sp-cAMPS (sodium salt)

Sp-cAMPS (sodium salt)

ArtNr	HY-100530C-10mM
Hersteller	MedChem Express
CAS-Nr.	142439-95-0
Menge	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.45
Citations	[1]Su H Hung, et al. A new nonhydrolyzable reactive cAMP analog, (Sp)-adenosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate irreversibly inactivates human platelet cGMP-inhibited cAMP phosphodiesterase. Bioorg Chem. 2002 Feb;30(1):16-31.\|[2]L Y Wang, et al. Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. Science. 1991 Sep 6;253(5024):1132-5.\|[3]Ronald Jäger, et al. Activation of PDE10 and PDE11 phosphodiesterases. J Biol Chem. 2012 Jan 6;287(2):1210-9.\|[4]P A Connelly,et al. A study of the mechanism of glucagon-induced protein phosphorylation in isolated rat hepatocytes using (Sp)-cAMPS and (Rp)-cAMPS, the stimulatory and inhibitory diastereomers of adenosine cyclic 3',5'-phosphorothioate. J Biol Chem. 1987 Mar 25;262(9):4324-32.\|[5]G Dominguez, et al. Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure. Brain Struct Funct. 2016 Mar;221(2):865-77.
Smiles	O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])O[P@](OC2)([S])=O)N3C4=C(C(N)=NC=N4)N=C3.[Na+]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Phosphodiesterase (PDE); PKA
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	367.25
Product Description	Sp-cAMPS sodium salt, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS sodium salt is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS sodium salt binds the PDE10 GAF domain with an EC50 of 40 μM[1][2][3].
Manufacturer - Research Area	Metabolic Disease; Neurological Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: 86.67 mg/mL (ultrasonic)
Manufacturer - Pathway	Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad
Isoform	PDE10; PDE3; PKA
Clinical information	No Development Reported

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HY-100530C-10mM-safety-datasheet.pdf