SGK1 Monoclonal Antibody

SGK1 Mouse (4D12)

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

IHC 1:100-200

Monoclonal

Monoclonal Antibodies