APH1 Antibody

ArtNr	ABC-ASC10486
Hersteller	Abcepta
Menge	100 ug
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Carcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Primary
Applikationen	WB, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Goutte C, Tsunozaki M, Hale VA, et al. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Natl. Acad. Sci. USA2002; 99:775-9. Periz G and Fortini ME. Functional reconstitution of γsecretase through coordinated expression of presenilin, nicastrin, aph-1, and pen-2. J. Neurosci. Res. 2004; 77:309-22. Selkoe DJ. The cell biology of βamyloid precursor protein and presenilin in Alzheimer’s disease. Trends Cell Biol. 1998; 8:447-53. Ma G, Li T, Price DL, et al. APH-1a is the principal mammalian aph-1 isoform present in g-secretase complexes during embryonic development. Neuro. Dis. 2005; 25:192-8.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	APH1 Antibody: APH-1,APH-1A,CGI-78,6530402N02Rik,PSF,UNQ579/PRO1141,Gamma-secretase subunit APH-1A,Aph-1alpha,APH-1a,anterior pharynx defective 1 homolog A (C. elegans)
Similar products	PSF, Gamma-secretase subunit APH-1A, Aph-1alpha, 6530402N02Rik, APH-1A, CGI-78, APH-1a, UNQ579/PRO1141, APH1 Antibody: APH-1, anterior pharynx defective 1 homolog A (C. elegans)
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Manufacturer - Category	Primary Antibodies; Neuroscience; Stem Cells
Manufacturer - Targets	APH1A;
Storage Conditions	APH1 antibody can be stored at 4? for three months and -20?, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Bio Background	APH1 Antibody: APH1 was initially identified as a component of the Notch pathway in C. elegans. Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the gamma-secretase complex which cleave the amyloid precursor protein (APP) at what are known as the gamma- and epsilon-sites and can lead to the accumulation of the Amyloid beta peptide (Abeta) cleavage product that is associated with Alzheimer's disease. APH1 exists in at least three distinct isoforms with APH1a as the principal isoform present in the gamma-secretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed.
Clonality	Polyclonal
Gene Name	APH1A
Reactivity	H, M, Rat
Calculated Molecular Weight	28996
Antigen Source	Homo sapiens
Purification	APH1 Antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	APH1 antibody can be used for detection of APH1 by Western blot at 0.5 - 1 µg/mL. Despite its predicted molecular weight, APH1 protein often migrates at aberrant locations in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 5 µg/mL.
Positive Control	Human Brain Tissue Lysate
Buffer	APH1 Antibody is supplied in PBS containing 0.02% sodium azide.

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