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PCK1 Antibody (monoclonal) (M01)

PCK1 Antibody (monoclonal) (M01)

ArtNr	ABC-AT3233a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, IF, IP
Clon	30000
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	PCK1, PEPCK1, Phosphoenolpyruvate carboxykinase, cytosolic [GTP], PEPCK-C
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Primary Accession	P35558
Antigen Type	Recombinant Protein
Application	WB, IF, IP
Bio Background	This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized.
Bio References	COMMON VARIANTS IN 40 GENES ASSESSED FOR DIABETES INCIDENCE AND RESPONSE TO METFORMIN AND LIFESTYLE INTERVENTIONS IN THE DIABETES PREVENTION PROGRAM. Jablonski KA, et al. Diabetes, 2010 Aug 3. PMID 20682687.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Rua?o G, et al. Pharmacogenomics, 2010 Jul. PMID 20602615.Intermediate phenotypes identify divergent pathways to Alzheimer's disease. Shulman JM, et al. PLoS One, 2010 Jun 21. PMID 20574532.Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
Clonality	Monoclonal
Gene ID	5105
Gene Name	PCK1 {ECO:0000303\|PubMed:8490617, ECO:0000312\|HGNC:HGNC:8724}
Subtitle	Mouse monoclonal antibody raised against a full length recombinant PCK1.
Reactivity	H
Legend image 1	Immunofluorescence of monoclonal antibody to PCK1 on HepG2 cell. [antibody concentration 10 ug/ml]
Type image 1	IF
Legend image 2	Immunoprecipitation of PCK1 transfected lysate using anti-PCK1 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with PCK1 MaxPab rabbit polyclonal antibody.
Type image 2	IP
Legend image 3	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (94.16 KDa) .
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	PCK1 monoclonal antibody (M01), clone 3E4 Western Blot analysis of PCK1 expression in HepG2 ( (Cat # AT3233a )
Type image 4	WB
Dilution image 4	1:500~1000
Legend image 5	Western Blot analysis of PCK1 expression in transfected 293T cell line by PCK1 monoclonal antibody (M01), clone 3E4. Lane 1: PCK1 transfected lysate(69.2 KDa). Lane 2: Non-transfected lysate.
Type image 5	WB
Dilution image 5	1:500~1000
Other Accession	BC023978
Isotype	IgG1 Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	PCK1 (AAH23978, 1 a.a. ~ 622 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_002582.3
	Clone: 30000
Org Accession	AAH23978
Gene Description	phosphoenolpyruvate carboxykinase 1 (soluble)
Gene Summary	This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq

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ABC-AT3233a-datasheet.pdf

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Menge: 100 ug

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