Neuromedin K receptor

GWB-637F20

This is a receptor for the tachykinin neuropeptide neuromedin K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: This protein belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5\' -end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This protein is the receptor for the tachykinin neurokinin 3 also referred to as neurokinin B. [1] Graham G. J. Stevens J. M. Page N. M. Grant A. D. Brain S. D. Lowry P. J. and Gibbins J. M. Tachykinins regulate the function of platelets[2] Krause J. E. Staveteig P. T. Mentzer J. N. Schmidt S. K. Tucker J. B. Brodbeck R. M. Bu J. Y. and Karpitskiy V. V. Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B and is responsive to tachykinin peptide agonists[3] Khawaja A. M. and Rogers D. F. et al. Tachykinins: receptor to effector[4] Xie G. X. Miyajima A. and Goldstein A. et al. Expression cloning of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands[5] Huang R. R. Cheung A. H. Mazina K. E. Strader C. D. and Fong T. M. et al. cDNA sequence and heterologous expression of the human neurokinin-3 receptor[6] Huang R. -R. C. Cheung A. H. Mazina K. E. Strader C. D. Fong T. M. cDNA sequence and heterologous expression of the human neurokinin-3 receptor. [7] Buell G. Schulz M. F. Arkinstall S. J. Maury K. Missotten M. Adami N. Talabot F. Kawashima E. Molecular characterisation expression and localisation of human neurokinin-3 receptor. [8] Takahashi K. Tanaka A. Hara M. Nakanishi S. The primary structure and gene organization of human substance P and neuromedin K receptors. [9] Kopatz S. A. Aronstam R. S. Sharma S. V. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org).