SARM1 Polyclonal Antibody

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Liquid solution

PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol.

Gel pack with blue ice.

SARM1 (Sterile Alpha And TIR Motif Containing 1) is a Protein Coding gene. Diseases associated with SARM1 include Wallerian Degeneration. Among its related pathways are Activated TLR4 signalling and IKK complex recruitment mediated by RIP1. GO annotations related to this gene include binding. Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.

Sterile alpha and TIR motif-containing protein 1; Sterile alpha and Armadillo repeat protein; Sterile alpha motif domain-containing protein 2; MyD88-5; SAM domain-containing protein 2; Tir-1 homolog

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