Rabbit Anti-Human CASP13/CASP4 pAb

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 b Converting Enzyme) and caspase-13, (1). Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines (1). This polyclonal antibody can be used for detection of AIF by Western blot at 0.5 to 1 ug/ml. HL60 cell lysate can be used as positive control and a 43 kDa band should be detected. It is human, mouse and rat reactive. For research use only.