Mouse Anti-Human PDGF-B (Clone 5F66) mAb

Stable below -20C. After reconstitution, stored in working aliquots below -20C for at least six months. Avoid repeated freeze-thaw cycles.

Platelet-Derived Growth Factor beta (PDFGB) is a member of the Platelet-Derived Growth Factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer (PDGF-AB) with Platelet-Derived Growth Factor alpha (PDGFA), where the dimers are connected by disulfide bonds. Mutations in the, PDGFB, gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for, COL1A1, are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Recombinant Human PDGF-BB

Centrifuge vial prior to opening. Reconstitute with sterile distilled water.