Rabbit Anti-Human BACE1 pAb

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Hersteller Cell Sciences
Kategorie
Typ Antibody
Specific against Human
Menge 100 ug
ArtNr CS-CPB000
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Applications
W
Description
Beta site APP cleaving enzyme (BACE-1), also identified as beta-secretase, is an aspartyl protease. The mature form of the enzyme is an N-glycosylated integral membrane protein with Mr=70 kDa. The N-glycosylation and carbohydrate trimming of immature BACE-1 are observed to take place within the Golgi apparatus. BACE-1 cleaves Amyloid Precursor Protein (APP), generating two fragments, the APP N terminal fragment (APPs-beta) with Mr=100 kDa and a smaller C-terminal fragment with Mr=12 kDa (C99). Subsequent cleavage of the smaller fragment by gamma-secretase produces beta-amyloid (A-beta). Improperly regulated production of beta-amyloid leads to deposition of amyloid plaques found in Alzheimer's disease, a neurodegenerative, dementia-inducing disorder. Cross reactivity with BACE-2 is almost negligible. Purity: Purified from rabbit serum by protein A/G affinity chromatography. Immunogen: The antiserum was produced against the solubilized total recombinant protein. Cross-reactivity:Human.

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Menge: 100 ug
Lieferbar: Out of stock
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