Antibodies

Rabbit Anti-Human CALR pAb

Hersteller Cell Sciences
Kategorie
Typ Antibody
Specific against Human
Isotype IgG
Applikationen WB
Menge 100 ug
Host Rabbit
ArtNr CS-CPC134
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Applications
Western Blot Immunohistochemistry
Description
Rabbit Anti-Human Calreticulin polyclonal antibody. Calreticulin is a calcium binding protein found in abundance in the endoplasmic reticulum and the sarcoplasmic reticulum. Like many other ER proteins, it has the conserved ER retention KDEL (Lys-Asp-Glu-Leu) sequence at its C-terminus. Calreticulin has also been detected in the nucleus and nuclear envelop. Recent studies suggest that this soluble ER protein has a multifunctional role as it appears to be involved in calcium storage and regulation as well as having a molecular chaperone activity. Studies also suggest its involvement in certain autoimmune diseases. Consistent with its multiple functions, the calreticulin molecule appears to have a zonal character. The protein has both high and low affinity calcium binding sites.
Formulation
Liquid in PBS + 30% glycerol + 0.5 mg/ml BSA + 0.01% thimerosal. Precaution: Thimerosal is a poisonous and hazardous substance which should be handled by trained staff only.
Specificity
Recognizes a 60 kDa calreticulin on SDS-PAGE immunoblots.
Immunogen
Synthetic peptide mapping to the C-terminus of human calreticulin
Purification
Affinity purified
Reconstitution
The antibody solution should be gently mixed before use.
Storage and Stability
Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles.
Concentration
0.2 mg/ml
Cross-Reactivity
Human, mouse, and rat
Application Notes
For Western Blot, use a working dilution of 0.5-4 ug/ml.For Immunoprecipitation, use a working dilution of 10-20 ug/ml.The optimal concentration should be determined by the user for each specific application.
Menge: 100 ug
Lieferbar: In stock
Listenpreis: 901,84 €
Preis: 901,84 €
lieferbar

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