Antibodies

Rabbit Anti-Human MAP3K14/NIK pAb

Hersteller Cell Sciences
Kategorie
Typ Antibody
Specific against Human
Isotype IgG
Applikationen IP
Menge 200 ug
Host Rabbit
ArtNr CS-CPN000
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Applications
W, IP
Description
Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14), also known as NF-kappa B-Inducing Kinase (NIK), is a member of the MAP kinase kinase kinase family that binds TNF Receptor Associated Factor 2 (TRAF2) and stimulates NF-kappa B activity. NIK was initially isolated from a Human B cell cDNA library. NIK is a serine/threonine kinase and its kinase activity contributes to I-kappa B phosphorylation. The C-Terminal segment of NIK binds TRAF2. A mutant NIK with intact C-Terminus but without the two lysine residues at its catalytic domain serves as a dominant-negative inhibitor for NF-kappa B activation. NIK also interacts with TNF Receptor Associated Factor 6 (TRAF6) and mediates IL1-induced NF-kappa B activation.
Formulation
Lyophilized with 0.1% Sodium Azide. Precaution: Sodium Azide is a poisonous and hazardous substance which should be handled by trained staff only.
Specificity
Human NIK
Immunogen
E. coli, -expressed Recombinant Human NIK fragment (aa 795-947)
Purification
Protein A purified
Reconstitution
Centrifuge vial prior to opening. Reconstitute to 1 mg/ml by adding 200 ul of distilled water.
Storage and Stability
Store at 2-4C for short term storage or at -20C in small aliquots for long term storage. Avoid repeated freeze-thaw cycles.
Cross-Reactivity
Cross reactivity to NIK of other species has not been determined.

Arbeitsanleitung

CS-CPN000.pdf

Menge: 200 ug
Lieferbar: In stock
Listenpreis: 380,15 €
Preis: 380,15 €
lieferbar

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Ihr Ansprechpartner:

Arne Pelz

sales@hoelzel.de