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Rabbit Anti-Human p53 Affinity Purified pAb

ArtNr CS-CPP138
Hersteller Cell Sciences
Menge 100 ug
Kategorie
Typ Antibody Polyclonal
Applikationen WB
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products TP53, P53, TRP53, Phosphoprotein p53, Tumor suppressor p53, LFS1
Lieferbar
Storage Conditions
Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles.
Application Notes
For Western Blot, use a working dilution of 0.5-4 ug/ml.Blocking Peptide (Cat. No. CPP138BP) is available separately.The optimal concentration should be determined by the user for each specific application. Other applications have not been determined.
Cross-Reactivity
Human, mouse, rat, dog, and rabbit
Description
p53, a 53 kDa protein, binds to a DNA consensus sequence, the p53 response element, and regulates normal cell cycle events by activating transcription of genes involved either in progression through the cell cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 5-1000 fold over the concentration in normal cells, principally due to the increased half-life (4 hrs) compared to that of wild-type (20 min). p53 localizes in the nucleus, but is detectable at the plasma membrane during mitosis and certain mutations also modulate cytoplasmic/nuclear distribution. p53 downregulates Bcl-2 expression and upregulates Bax expression, but may not always be necessary for apoptosis.
Formulation
100 ug (0.5 mg/ml) affinity purified rabbit anti-p53 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol + 0.5% BSA + 5 mM EDTA + 0.01% thiomersal. Precaution: Thiomersal is a poisonous and hazardous substance which should be handled by trained staff only.
Immunogen
Synthetic peptide corresponding to residue surrounding amino acid 375 of human p53
Purification
Affinity purified
Specificity
p53
Concentration
0.5 mg/ml

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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