Rabbit Anti-Human VEGFR1/FLT1 pAb

Hersteller Cell Sciences
Kategorie
Typ Antibody
Specific against Human
Isotype IgG
Applikationen WB, ELISA
Menge 100 ug
Host Rabbit
ArtNr CS-CPV004A
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Applications
Western blot: Use at 1-5 ug/ml ELISA: Use at 2.5 ug/ml Immunoprecipitation: Use 1-5 ug/ml
Description
Rabbit Anti-human VEGFR1/FLT1 polyclonal antibody. Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes, dendritic cells and on trophoblast cells. The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular splited tyrosine kinase domain. Compared to VEGFR-2 the Flt-1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR-1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Interestingly a naturally occuring soluble variant of VEGFR-1 (sVEGFR-1) was found in HUVE supernatants in 1996, which is generated by alternative splicing of the flt-1 mRNA.
Formulation
Lyophilized from PBS.
Immunogen
Recombinant human soluble Flt1 (D1-5).
Purification
Protein A chromatography
Reconstitution
Centrifuge vial prior to opening. Add sterile distilled water to a concentration of 0.1-1.0 mg/mL.
Storage and Stability
Lyophilized antibody is stable at room temperature for up to one month but is best stored at -20C. After reconstitution, stable for two weeks in working aliquots at 2-8C. Frozen aliquots are stable for at least six months when stored at -20C. Avoid repeated freeze-thaw cycles.
Menge: 100 ug
Lieferbar: In stock
Listenpreis: 398,34 €
Preis: 398,34 €
lieferbar

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