Mouse Anti-Human Tau CSSA Clone TauC3 mAb

Western blot: recommended concentration is 1 ug/ml. The optimal concentration should be determined by the user for each specific application.

Mouse Anti-tau (421/422) Clone TauC3 CSSA mAb

KLH-CSSTGSIDMVD, corresponding to the C terminus of tau truncated at Asp421.

This antibody recognizes tau when truncated at Asp421. Several caspases, including caspase-3, caspase-7, and caspase-8, cleave tau at this site, yielding the truncated form of the protein. This antibody does not react with full-length tau, or with tau truncated at Glu391 or Ala429. Tau is a microtubule-associated protein found predominantly in neuronal axons of vertebrate brain that promotes the assembly of tubulin monomers into microtubules and stabilizes microtubules. Hyperphosphorylation impairs the microtubule binding function of tau. Hyperphosphorylated tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer’s disease (AD) brain. The truncation state of tau can influence many of its pathologic characteristics, including its ability to assume AD-related conformations and to assemble into filaments. Recent data suggest that Abeta can trigger caspase activation and cell apoptosis. Caspase cleavage of tau at Asp 421 at the C-terminus is an important inducer of tau polymerization in Alzheimer's disease. This antibody provides a tool for studying neuronal cell apoptosis.