Rabbit Anti-Human ANAPC2 Clone Poly6108 pAb

APC2 (anaphase-promoting complex subunit 2) is a member of the E3 enzyme family. This protein contains cullin repeats and has a molecular weight of approximately 105 kD. The APC2 protein is located in the nucleus during interphase, and at the centrosome during metaphase/anaphase. This protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC2 protein functions as a probable catalytic subunit, a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition, and spindle elongation. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1. The APC2 protein interacts with Rad51 (as well as the APC complex proteins noted above). The Poly6108 antibody has been shown to be useful for Western blot of the human and mouse APC2 protein.

Recombinant (partial), N-terminal