Mouse Anti-Human CD37 (Clone IPO-24) mAb

Antibodies

MON1035 can be used in immunohistochemistry for both frozen and paraffin sections, flow cytometry and ELISA.

The antigen CD37 defined by IPO-24 is B lineage restricted and is strongly expressed throughout B cell ontogeny from pre-B cells untill the plasmoblasts. CD37 is an extensively glycosylated molecule and usually two and sometimes three N-linked carbohydrate chain are attached to the protein. IPO-24 reacts with human B cell lines Daudi, Raji, Namalva, Ramos and CABIL, whereas T cell lines CEM, Molt-4, Jurkat, MT-4, H9 and non-lymphoid cell lines MeWo and A-431 are not labeled. IPO-24 stains B cell follicles and the most strongly labeled elements are mantle zone lymphoid cells. Neutrofils, macrophages, thymocytes and dendritic reticulum cells are negative. Source: IPO-24 was generated after immunization of BALB/c mice with spleen cells of a patient with hairy cell leukemia. Mice splenocytes were fused with the P3-X63-Ag8.653 mouse myeloma cell line.