Mouse Anti-Human CD46 (Clone MEM-258) mAb

Antibodies

100 ug in solution (PBS containing 15 mM sodium azide, pH 7.4). Precaution: Sodium azide is a poisonous and hazardous substance which should be handled by trained staff only.

CD46 antigen (human). The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome.