Mouse Anti-Human TLR3 Clone TLR3.7 mAb

Product should be stored at 4C. Under recommended storage conditions, product is stable for one year.

The monoclonal anibody TLR3.7 reacts with human Toll-like receptors 3 (TLR3, CD283). TLRs are highly conserved throughout evolution and have been implicated in the innate defence to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defences. In mammals, TLRs identified as type I transmembrane signalling receptors with pattern recognition capabilities, have been implicated in the innate host defence to pathogens. As investigated so far all functional characterized TLR signal via the TLR/IL-1 receptor (IL-1R) pathway where recruitment of MyD88 seems to be essential. Viral replication within infected cells results in generation of dsRNA which can stimulate immune cells. Recent data show that TLR3 (CD283) acts as a receptor involved in the recognition of dsRNA, indicating a role for TLR3 in viral recognition and innate defence. The monoclonal antibody TLR3.7 is cross reactive with canine TLR3.