Rabbit Anti-Human TRAILR1/DR4 (CT) pAb

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4)1. The ligand for this novel death receptor has been identified and termed TRAIL2, 3, which, is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1)4. DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells. This polyclonal antibody can be used for detection of DR4 expression by Western blot at 1:500 to 1:1000 dilution. HeLa whole cell lysate can be used as positive control and a 57 kDa band should be detected. It is human, mouse, and rat reactive and has no cross reaction to DR5. For research use only.