Rabbit Anti-Human DAXX (CT) pAb

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular from mouse, human and monkey and designated Daxx1, 2. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways1, 2. This polyclonal antibody can be used for detection of Daxx by Western blot at 1:500 to 1:1000 dilution. HeLa whole cell lysate can be used as positive control and a 120 kDa major band can be detected. The sequences of immunogenic peptide are identical among human, monkey and mouse origins of Daxx1, 2, and the antibody recognizes Daxx from all these species. For research use only.