Rabbit Anti-Human MAP3K14/NIK (CT) pAb

Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa, LPS and mitogens. A serine/threonine protein kinase which mediates NF-kB activation by IL-1, TNFa and CD95 was identified recently and designated NIK (for NF-kB inducing kinase) (1). NIK is an activator of IkB kinase alpha and beta (IKKa and IKKb) (2-5). Therefore, NIK is a key molecule in the NF-kB signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products. This polyclonal antibody can be used for detection of NIK by Western blot. 293 cell lysate can be used as positive control.