Rabbit Anti-Human APP (CT) Affinity Purified pAb

Accumulation of the amyloid-b peptide (Ab) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The b-amyloid protein precursor (APP) is cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide (Ab), which is deposited in the brains of all suffers of Alzheimer’s disease. This polyclonal antibody can be used for detection of APP and the C99 fragment by Western blot at 1:500 to 1:1000 dilution. Murine brain lysate can be used as positive control. It is human, mouse, and rat reactive. This antibody is for research use only.