Rabbit Anti-Human IL-21R (NT) Affinity Purified pAb

A novel cytokine related to IL2 and IL15 was recently identified and designated IL-21 (1). The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1, 2). IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling (3, 4). Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations. This antibody can be used for detection of IL-21R by Western blot at 0.5 to 1 mg/ml. Human Raji and A431 cell lysates can be used as positive control and an approximately 60 kDa band can be detected. For research use only.