Rat Anti-Mouse IL-1R2 Clone 7D7 mAb

Rat Anti-Mouse IL1R2 monoclonal antibody Clone 7D7. IL1 receptor type II (IL1R-II) is a 65 kD member of the immunoglobulin superfamily also known as IL1 receptor (IL1R) type II. The IL1R family is composed of three proteins: IL1R type I, IL1R type II, and the widely expressed IL1R AcP. Both IL1R type I and type II bind IL1a and IL1beta, although with differing affinities. The high affinity complex consists of IL1R type I and IL1R AcP, whereas IL1 binds to IL1R type II with low affinity. The IL1 receptor antagonist (IL1RA) can bind to both IL1R type I and II. IL1R type II is expressed at low levels on B-cells, monocytes/macrophages, neutrophils, basal epithelia of the skin, and T-cells. Binding of IL1 to the high affinity IL1 receptor mediates thymocyte and T-cell activation, fibroblast proliferation, and induction of acute phase protein production. Binding of IL1 to CDw121b appears to be dispensable for IL1 signaling and may negatively regulate IL1 responses acting as a "decoy" receptor.

Recombinant extracellular domain of mouse IL1R2

Centrifuge vial prior to opening. Reconstitute with 200 ul sterile PBS (final concentration 500ug/ml).

Recognizes mouse IL1R2