Description |
Rat Anti-Mouse IL1R1 Clone 11B7 monoclonal antibody. IL1R1 is an 80 kDa transmembrane glycoprotein and a member of the immunoglobulin superfamily expressed on T-cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. IL1R1 binds the mature forms of IL1-alpha, IL1-beta, and IL1Ra proteins. High affinity binding and signaling by IL1R1 requires CD121a and the accessory protein, IL1R AcP, which does not bind IL1 alone, but forms a dimer capable of binding IL1. |