Antibodies

Mouse Anti-Mouse LBP Clone biG 33 mAb

Hersteller Cell Sciences
Kategorie
Typ Antibody
Specific against Mouse
Clon biG33
Isotype IgG1
Applikationen WB, ELISA
Menge 100 ug
ArtNr CS-CML001
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Applications
ELISA, Western blot, and LBP inhibition studies. Inhibits binding of LPS to membrane bound CD14. Inhibits LPS-binding (0.5 ug/ml) to CD14+ CHO cells (2 x 106/ml) up to 1:1, 000, total inhibition 1:5. Binding titer for mouse LBP ELISA: 1:50, 000. The optimal concentration should be determined by the user for each specific application.
Description
Mouse monoclonal antibody against mouse LBP Clone biG 33 made in knockout mice. LBP is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP).
Formulation
Lyophilized in PBS without preservatives or additives
Specificity
Mouse LBP
Host info
LBP-Knockout Mouse
Immunogen
Immunoaffinity purified recombinant mouse LBP
Purification
Protein G purified
Reconstitution
Centrifuge vial prior to opening. For reconstitution, add 100 ul of distilled water to obtain 1 mg/ml.
Storage and Stability
Store long term at -20C or -80C. Avoid repeated freeze-thaw cycles.
Concentration
1 mg/ml
Cross-Reactivity
Cross-reacts with rat and human LBP.
Menge: 100 ug
Lieferbar: In stock
Listenpreis: 488,97 €
Preis: 488,97 €
lieferbar

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Arbeitsanleitung

CS-CML001.pdf