Rabbit Anti-Mouse Casp2 Affinity Purified pAb

Rabbit Anti-Mouse Caspase 2 Affinity Purified polyclonal antibody. Caspases play a key role in apoptosis. Similar to other caspases, caspase 2 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Caspase 2 mRNA is alternatively spliced. The larger mRNA species encoding a product of 435 amino acids is known as ICH-1L. The smaller mRNA species encoding a protein of 312 amino acids is named ICH-1S. Over expression of ICH-1L induces apoptosis, while over expression of ICH-1S suppresses Rat-1 cell death induced by serum deprivation.

Detects the full length and small subunit of caspase 2. In human samples, it also detects a 30 kDa intermediate fragment.

Biospecific affinity chromatography

Reacts with human, mouse, and rat.