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Rabbit Anti-Mouse PARP1 Affinity Purified pAb

Rabbit Anti-Mouse PARP1 Affinity Purified pAb

ArtNr	CS-CPP144
Hersteller	Cell Sciences
Menge	100 ug
Kategorie	Oncology Antibodies By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Cell Biology Cytoskeleton Western Blot Primary Antibodies small GTPases Arf Subfamily
Typ	Antibody Polyclonal
Applikationen	WB
Specific against	Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	PARP1, PPOL, ADPRT, NAD(+) ADP-ribosyltransferase 1
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Storage Conditions	Store at -20C. For long term storage, aliquot and freeze at -80C. Avoid repeated freeze/defrost cycles.
Application Notes	Western blot analysis (0.5-4 ug/ml) and immunocytochemistry (10-20 ug/ml). However, the optimal concentrations should be determined individually. The polyclonal anti-cleaved PARP antibody recognizes only the large fragment of PARP (89 kDa) and does not react with the full length PARP.
Description	PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases, in vitro, and is one of the main cleavage targets of caspase-3, in vivo . The cleavege occurs between ASP214 and Gly 215, which separates PARP’s N-terminal DNA binding domain (24 kDa) from its C-terminal catalytic domain (89 kDa). It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis, in vitro .
Formulation	100 ug (0.2 mg/ml) affinity purified rabbit polyclonal anti-cleaved PARP antibody in phosphate-buffered saline (PBS) containing 50% glycerol + 1% BSA and 0.02% thiomersal. Precaution: Thiomersal is a poisonous and hazardous substance which should be handled by trained staff only.
Immunogen	Synthetic peptide corresponding to the C-terminus adjacent to Asp214 of mouse PARP
Purification	Affinity purified
Specificity	The antibody recognizes only the large fragment of PARP (89 kDa) and does not react with the full length PARP.
Concentration	0.5 mg/ml

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CS-CPP144-datasheet.pdf

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Menge: 100 ug

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Lieferung vsl. bis 17.07.2025

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