Rat Anti-Mouse TLR4 Clone MTS510 Biotin mAb

Product should be store at 4C. Under recommended storage conditions, product should be stable for one year.

The monoclonal antibody MTS510 reacts with the Toll-like receptor 4 (TLR4, CD284) /MD-2. TLRs are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila, toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defense. In mammals, TLRs identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defence to pathogens. TLR4 has been identified next to MD-2 and CD14 as a receptor that is central to the innate immune response to lipopolysaccharides (LPS) of Gram-negative bacteria. The monoclonal antibody MTS510 reacts preferentially, especially in flow cytometry, with mouse TLR4 that is associated with MD-2. MTS510 is a TLR4 function-blocking antibody that is useful for studies on the role of TLR4 as a receptor for LPS induced cytokine production by TLR4 bearing cells. The antibody was shown to coprecipitate MD-2 (30 kDa) with TLR4 (100 kDa).