Rabbit Anti-Mouse Survivin (CT) Affinity Purified pAb

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP (1-3). Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas (1, 3). This polyclonal antibody can be used for detection of survivin by Western blot at 0.5 to 1 ug/ml. Mouse spleen tissue lysate can be used as positive control and an approximate 17 kDa band can be detected. For research use only.