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Rabbit Anti-Rat Hsp27 Affinity Purified pAb

ArtNr CS-CPH102
Hersteller Cell Sciences
Menge 100 ug
Kategorie
Typ Antibody Polyclonal
Applikationen WB
Specific against Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products HSPB1, HSP27, HSP28, CMT2F, DKFZp586P1322, HS.76067, Hsp25
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Storage Conditions
Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles.
Application Notes
For Western Blot, use a working dilution of 0.5-4 ug/ml.Rat kidney tissue lysate can be used as a positive control.Blocking Peptide (Cat. No. CPH102BP) is available separately.The optimal concentration should be determined by the user for each specific application.
Cross-Reactivity
Rat
Description
HSPB1 exhibits a chaperone-like activity by serving as a site where unfolding proteins may bind until ATP and HSP70-dependent refolding can occur. HSPB1 is believed to protect cells by enhancing cellular glutathione levels and elevated glutathione levels have been measured in cells overexpressing HSPB1. Data from studies using wild-type HSPB1 and mutant forms in which the serine phosphorylation sites were mutated to alanines, glycines or aspartates, have shown that cellular glutathione levels depend on the oligomerization of HSPB1. Recent findings indicate that HSPB1 is also a negative regulator of cytochrome c-dependent activation of procaspase-3.
Formulation
100 ug (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol + 0.5% BSA + 0.01% thiomersal. Precaution: Thiomersal is a poisonous and hazardous substance which should be handled by trained staff only.
Immunogen
Synthetic peptide surrounding amino acid 193 or rat HSPB1
Purification
Biospecific affinity chromatography
Specificity
The antibody detects 27 kDa rat Hsp27. Rat kidney tissue lysate can be used as a positive control.
Concentration
0.5 mg/ml

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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