Native Human IGFBP1

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 20 ug
ArtNr CS-BP1BU020
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
Native human Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) is a 218 amino acid protein that is a member of a family of six circulating proteins which bind IGF-I and IGF-II with high affinity and modulate their metabolic and mitogenic effects. The liver, ovarian granulosa cells, decidualized endometrium and a number of other cell types produce native human IGFBP-1. IGFBP-1 binds both IGF-I and IGF-II. Serum IGFBP-1 levels are regulated by insulin-induced inhibition of IGFBP-1 production. IGFBP-1 appears to inhibit smooth muscle migration in response to IGF-I or IGF-II and to stimulate wound healing in response to IGF-II.
Source
Purified from human amniotic fluid of individuals that have been shown by certified tests to be negative for hepatitis.
Molecular Weight
23.5 kDa
Purity
Greater than 95% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per ug (1EU/ug).
Biological Activity
Inhibition of IGF-I stimulated proliferation of NUC-1 cells: IC50 ca. 100 ng/ml. Inhibition of serum-induced stimulation of DNA synthesis in chick embryo fibroblast primary cultures: IC50 (1% serum) ca.300 ng/ml.
Format
Lyophilized
Menge: 20 ug
Lieferbar: In stock
Listenpreis: 543,94 €
Preis: 543,94 €
lieferbar

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