Recombinant Human IGFBP3

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 20 ug
ArtNr CS-BP3BU020
Eclass 6.1 34160400
Eclass 9.0 42020190
Lieferbar
Description
Human Insulin-like Growth Factor Binding Protein-3 (hIGFBP-3) is a 264 amino acid protein that is one of the six iclassicali IGF binding proteins that play an important role in stabilizing and regulating the activity of IGFs in vivo. Human IGFBP-3 is a 40-44 kDa glycoprotein that is the most abundant IGFBP in serum and milk. It is produced by non-parenchymal hepatic cells and circulates in serum, binding IGF-I or IGF-II in conjunction with an acid labile subunit (ALS) to form a (1:1:1) 150 kDa circulating complex at a serum concentration of about 100 nM. Free IGF-I has a half-life of ca.10 min in serum. This can be increased to ca.25 min if bound to IGFBP-3 and to ca.15 h if complexed with IGFBP-3 and ALS.
Source
Produced recombinantly in mammalian cells. Purified by affinity chromatography and HPLC.
Molecular Weight
43 - 45 kDa
Purity
Greater than 95% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per ug (1EU/ug).
Biological Activity
Characteristic doublet of glycoforms detected by Western ligand blot using mono-biotinyl IGF-II as probe.
Format
Lyophilized
Menge: 20 ug
Lieferbar: In stock
Listenpreis: 494,49 €
Rabatt: -10,0%
Preis: 445,04 €
Sie sparen: 49,45 €
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Arbeitsanleitung

CS-BP3BU020.pdf