Synthetic Human ACTH/Adrenocorticotropic Hormone

Lyophilized Adrenocorticotropic Hormone although stable at room temperature for 3 weeks, should be stored desiccated below -20C. Upon reconstitution ACTH should be stored at 4C between 2-7 days and for future use below -20C. For long term storage it is recommended to add a carrier protein 0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.

Adrenocorticotropic hormone, as its name implies, stimulates the adrenal cortex. More specifically, it stimulates secretion of glucocorticoids such as cortisol, and has little control over secretion of aldosterone, the other major steroid hormone from the adrenal cortex. Stimulates secretion of adrenal corticosteroids and induces growth of adrenal cortex. ACTH also called Tetracosactide directly activates G-proteins. A stimulator of adenylate cyclase and cAMP formation. Its molecular weight is 4541.3 having an amino acid sequence of H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH.

Centrifuge vial prior to opening. It is recommended to reconstitute the lyophilized ACTH in sterile distilled water not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.