Recombinant Human 4-1BB Ligand

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 20 ug
Host E.coli
ArtNr CS-CRB200B
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
4-1BBL is a member of the tumor necrosis factor (TNF) receptor family. This receptor contributes to the clonal expansion, survival, and development of T cells. In addition, 4-1BBL expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. CD137 has been shown to interact with TRAF2. The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 205 amino acid extracellular domain (ECD). The human 41BBL ECD shares 32% and 35% a.a. identity with mouse and rat ECD.
Formulation
Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Reconstitution
Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.
Storage and Stability
This lyophilized preparation is stable at 2-4C, but should be kept desiccated at -20C for long term storage. Upon reconstitution, the preparation is stable for up to one week at 2-4C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -80C. Avoid repeated freeze/thaw cycles.
GeneID
8744
Source
E. coli
Molecular Weight
19.4 kDa
Purity
Greater than 95% by SDS-PAGE and HPLC analyses.
Specific Activity
> 1.0 x 10E5 IU/mg.
Endotoxin Level
Less than 1 EU/ug of rHu4-1BBL as determined by LAL method.
Biological Activity
Fully biologically active when compared to standard. The ED50 determined by stimulation of IL-8 production using human PBMC is less than 10 ng/ml.
AA Sequence
REGPELSPDD PAGLLDLRQG MFAQLVAQNV LLIDGPLSWY SDPGLAGVSL TGGLSYKEDT KELVVAKAGV YYVFFQLELR RVVAGEGSGS VSLALHLQPL RSAAGAAALA LTVDLPPASS EARNSAFGFQ GRLLHLSAGQ RLGVHLHTEA RARHAWQLTQ GATVLGLFRV TPEIPAGLPS PRSE
Menge: 20 ug
Lieferbar: In stock
Listenpreis: 349,81 €
Preis: 349,81 €
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