Vergleich

Recombinant Human 4-1BB Ligand

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 20 ug
Host E.coli
ArtNr CS-CRB200B
Targets TNF
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Biological Activity
Fully biologically active when compared to standard. The ED50 determined by stimulation of IL-8 production using human PBMC is less than 10 ng/ml.
Description
4-1BBL is a member of the tumor necrosis factor (TNF) receptor family. This receptor contributes to the clonal expansion, survival, and development of T cells. In addition, 4-1BBL expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. CD137 has been shown to interact with TRAF2. The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 205 amino acid extracellular domain (ECD). The human 41BBL ECD shares 32% and 35% a.a. identity with mouse and rat ECD.
Endotoxin Level
Less than 1 EU/ug of rHu4-1BBL as determined by LAL method.
Formulation
Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Molecular Weight
19.4 kDa
Reconstitution
Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.
Storage and Stability
This lyophilized preparation is stable at 2-4C, but should be kept desiccated at -20C for long term storage. Upon reconstitution, the preparation is stable for up to one week at 2-4C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -80C. Avoid repeated freeze/thaw cycles.
Specificity
> 1.0 x 10E5 IU/mg.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 20 ug
Lieferbar: In stock
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Lieferung vsl. bis 18.04.2024 

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