Recombinant Human CTLA4/CD152

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 25 ug
ArtNr CS-CRC012B
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
Recombinant human CTLA-4/CD152 is a homodimeric, glycosylated polypeptide chain. Each subunit (40 kDa) is fused to a polypeptide linker to the Fc portion of human IgG1. CTLA-4 is expressed in low copy number by T-cells only after activation, but it binds CD28-ligand with approximately 20-fold higher affinity than CD28. A soluble form of the extracellular domain of CTLA-4 has been shown to bind CD28-ligand with high avidity and to suppress T-cell-dependent antibody responses, in vivo . Large doses of this soluble protein also suppress responses to a second immunization.
Formulation
Lyophilized from a sterile filtered solution without additives
Reconstitution
Centrifuge vial prior to opening. First add sterile distilled water to the vial to fully solubilize the protein to a concentration not less than 100 ug/ml. After complete solubilization of the protein, it can be further diluted to other aqueous solutions.
Storage and Stability
Store lyophilized protein at -20C to -80C. Reconstituted protein is stable for 1 week in working aliquots. For long term storage, aliquot and store at -20C to -80C with a carrier protein (0.1% HSA or BSA) as a stabilizer. Please note that the addition of any carrier protein into this product may produce unwanted endotoxin. This depends upon the particular application employed. Avoid repeated freeze-thaw cycles.
GeneID
1493
Source
Sf9 cells
Molecular Weight
80.0 kDa
Purity
> 95% as determined by RP-HPLC and SDS-PAGE analyses
Endotoxin Level
< 0.1 ng/ug of CTLA4
AA Sequence
The sequence of the first five N-terminal amino acids is Lys-Ala-Met-His-Val.
Menge: 25 ug
Lieferbar: In stock
Listenpreis: 428,68 €
Preis: 428,68 €
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