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Recombinant Human CTLA4/CD152

Recombinant Human CTLA4/CD152

Hersteller	Cell Sciences
Kategorie	Oncology By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins
Typ	Proteins
Specific against	Human
Menge	25 ug
ArtNr	CS-CRC012B
Targets	CD152
eClass 6.1	34160400
eClass 9.0	42020190
Lieferbar
Description	Recombinant human CTLA-4/CD152 is a homodimeric, glycosylated polypeptide chain. Each subunit (40 kDa) is fused to a polypeptide linker to the Fc portion of human IgG1. CTLA-4 is expressed in low copy number by T-cells only after activation, but it binds CD28-ligand with approximately 20-fold higher affinity than CD28. A soluble form of the extracellular domain of CTLA-4 has been shown to bind CD28-ligand with high avidity and to suppress T-cell-dependent antibody responses, in vivo . Large doses of this soluble protein also suppress responses to a second immunization.
Endotoxin Level	< 0.1 ng/ug of CTLA4
Formulation	Lyophilized from a sterile filtered solution without additives
Molecular Weight	80.0 kDa
Reconstitution	Centrifuge vial prior to opening. First add sterile distilled water to the vial to fully solubilize the protein to a concentration not less than 100 ug/ml. After complete solubilization of the protein, it can be further diluted to other aqueous solutions.
Storage and Stability	Store lyophilized protein at -20C to -80C. Reconstituted protein is stable for 1 week in working aliquots. For long term storage, aliquot and store at -20C to -80C with a carrier protein (0.1% HSA or BSA) as a stabilizer. Please note that the addition of any carrier protein into this product may produce unwanted endotoxin. This depends upon the particular application employed. Avoid repeated freeze-thaw cycles.

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