Recombinant Human EFNB1 His

Recombinant Human Ephrin-B1 is comprised of aa 136-247 of the full length protein and is purified by proprietary chromatographic techniques. Ephrin-B1 is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. Ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases. Based upon their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are attached to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Class A ephrins are linked to the membrane by a GPI linkage and bind primarily to EphA receptors, Class B ephrins contain a membrane-spanning region and bind primarily to EphB receptors. Ephrin-B1 binds to the receptor tyrosine kinases ephb1 and epha1. Both ephrins and Eph receptors are largely expressed throughout the ectoderm, mesoderm, and endoderm of vertebrate embryos. Ephrin-B1 may play a role in cell adhesion and function in the development or maintenance of the nervous system. It binds to and induces the collapse of commissural axons/growth cones, in vitro . Ephrin-B1 may play a role in constraining the orientation of longitudinally projecting axons (by similarity). Defects in the efnb1 gene are a cause of craniofrontonasal syndrome (CFNS), also known as craniofrontonasal dysplasia (CFND).

47 kDa by SDS-PAGE