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Recombinant Human Endogenous VEGFR-1, soluble

ArtNr CS-CRF103B
Hersteller Cell Sciences
Menge 20 ug
Kategorie
Typ Proteins
Specific against Human (Homo sapiens)
Host Insect
Purity >95% by SDS-PAGE and visualized by silver stain
Sequence SGSKLKDPEL SLKGTQHIMQ AGQTLHLQCR GEAAHKWSLP EMVSKESERL SITKSACGRN GKQFCSTLTL NTAQANHTGF YSCKYLAVPT SKKKETESAI YIFISDTGRP FVEMYSEIPE IIHMTEGREL VIPCRVTSPN ITVTLKKFPL DTLIPDGKRI IWDSRKGFII SNATYKEIGL LTCEATVNGH LYKTNYLTHR QTNTIIDVQI STPRPVKLLR GHTLVLNCTA TT
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Similar products VEGFR1, vascular permeability factor receptor, VEGFR-1, FLT, vascular endothelial growth factor receptor 1, FLT-1, fms-like tyrosine kinase 1, tyrosine-protein kinase FRT, tyrosine-protein kinase receptor FLT
Lieferbar
Manufacturer - Category
Biomolecules
Storage Conditions
Lyophilized protein is stable for 6 months at -20C to -80C. Store reconstituted protein in working aliquots at -20C. Avoid repeated freeze-thaw cycles.
Molecular Weight
96 kDa
Description
Recombinant Human soluble VEGFR1 is the naturally occurring form and was cloned from total RNA of human uMbilical vein endothelial cells. The recombinant mature soluble VEGFR1 is a glycosylated monomeric protein with a mass of approximately 96 kDa consisting of the first 6 extracellular domains (Met1-His688) and containing 31 unique amino acid residues at the C-terminus. Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR1 (FLT1), VEGFR2 (KDR/FLK1), and VEGFR3 (FLT4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR1 can also be found on monocytes, dendritic cells and on trophoblast cells. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. Compared to VEGFR2 the FLT1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Interestingly, a naturally occuring soluble variant of VEGFR1 (sVEGFR1) was found in HUVEC supernatants in 1996, which is generated by alternative splicing of the FLT1 mRNA. The biological functions of sVEGFR1 still are not clear, but it seems to be an endogenous regulator of angiogenesis, binding VEGF with the same affinity as the full length receptor.
Formulation
Lyophilized from PBS
Reconstitution
Centrifuge vial prior to opening. Soluble in water and most aqueous buffers. Add PBS to the vial to fully solubilize the protein to a concentration not lower than 100 ng/ml.
Biological Activity
Determined by its ability to inhibit the VEGF-A-induced proliferation of HUVECs.
Endotoxin Level
< 0.1 ng/ug of VEGFR1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 20 ug
Lieferbar: In stock
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