| Description |
Ghrelin (‘ghre’ is the Proto-Indo-European root of the word ‘grow’) has been identified as the endogenous ligand for the GHS-R (growth homone secretagogues receptor). Ghrelin is expressed in the stomach, small and large intestines, and brain regions, that are involved in the regulation of food intake. Both ghrelin and GHS-R expression is also detected in the heart, suggesting that Ghrelin might have some cardiovascular effects. Ghrelin administration stimulates GH secretion but also causes weight gain by increasing food intake. Mature human and rat Ghrelin (28 a.a.) are produced from 117 amino acid procursor. Ghrelin has an unusual modification-a Ser3 residue that is n-octanoylated and is essential for biological activity. Ghrelin is the first known example of a bioactive peptide modified by an acyl acid. |
