Recombinant Human GNMT (aa 1-295) His

Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -80C. Avoid repeated freezing and thawing cycles.

Glycine N-methyltransferase, also known as GNMT, catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. This protein affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and participates in the detoxification pathway in liver cells. Also, it is reported that GNMT expression is diminished in human hepatocellular carcinoma (HCC). Recombinant human GNMT protein, fused to His-tag at N-terminus, was expressed in, E. coli, and purified by using conventional chromatography techniques.

< 1.0 EU per 1"¶ of protein (determined by LAL method)